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Prevention of NMSCs*

*Includes treatment of actinic keratoses as a mechanism for prevention of NMSC and use of sirolimus to prevent NMSCs

Muranushi C, Olsen CM, Pandeya N, Green AC. Aspirin and Non-steroidal Anti-inflammatory Drugs Can Prevent Cutaneous Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. J Invest Dermatol. 2014 Dec 18. 

Singh A, Singh A, Sand JM, Bauer SJ, Bin Hafeez B, Meske L, et al. Topically Applied Hsp90 Inhibitor 17AAG Inhibits Ultraviolet Radiation-Induced Cutaneous Squamous Cell Carcinomas. J Invest Dermatol. 2014 Oct 22. 

Tang JY, Chiou AS, Mackay-Wiggan JM, Aszterbaum M, Chanana AM, Lee W, et al. Tazarotene: Randomized, Double Blind, Vehicle-Controlled and Open-Label Concurrent Trials for Basal Cell Carcinoma Prevention and Therapy in Patients with Basal Cell Nevus Syndrome. Cancer Prev Res (Phila). 2014 Jan 17. 

Hoogendijk-van den Akker JM, Harden PN, Hoitsma AJ, Proby CM, Wolterbeek R, Bouwes Bavinck JN, et al. Two-Year Randomized Controlled Prospective Trial Converting Treatment of Sable Renal Transplant Recipients with Cutaneous Invasive Squamous Cell Carcinomas to Sirolimus. Jouranl of Clinical Oncology. 2013 Jan 28.

Basset-Seguin N, Baumann Conzett K, Gerritsen MJ, Gonzalez H, Haedersdal M, Hofbauer GF, Aguado L, Kerob D, Lear JT, Piaserico S, Ulrich C. Photodynamic therapy for actinic keratosis in organ transplant patients. J Eur Acad Dermatol Venereol. 2013 Jan;27(1):57-66. doi: 10.1111/j.1468-3083.2011.04356.x. Epub 2011 Dec 10. PubMed PMID: 22151793.

Campbell SB, Walker R, Tai SS, Jiang Q, Russ GR. Randomized controlled trial of sirolimus for renal transplant recipients at high risk for nonmelanoma skin cancer. Am J Transplant. 2012 May;12(5):1146-56. doi: 10.1111/j.1600-6143.2012.04004.x. Epub 2012 Mar 15. PubMed PMID: 22420843. 

Lien MH, Fenske NA, Glass LF. Advances in the chemoprevention of non-melanoma skin cancer in high-risk organ transplant recipients. Semin Oncol. 2012 Apr;39(2):134-8. doi: 10.1053/j.seminoncol.2012.01.001. Review. PubMed PMID: 22484184. 

Gupta AK, Paquet M, Villanueva E, Brintnell W. Interventions for actinic keratoses. Cochrane Database Syst Rev. 2012 Dec 12;12:CD004415. doi: 10.1002/14651858.CD004415.pub2. PubMed PMID: 23235610.

Lebwohl M, Swanson N, Anderson LL, Melgaard A, Xu Z, Berman B. Ingenol mebutate gel for actinic keratosis. N Engl J Med. 2012 Mar 15;366(11):1010-9. doi: 10.1056/NEJMoa1111170. PubMed PMID: 22417254.

Mihalis E, Wysong A, Boscardin WJ, Tang JY, Chren MM, Arron ST. Factors Affecting Sunscreen Use and Sun Avoidance in a U.S. National Sample of Organ Transplant Recipients. Br J Dermatol. 2012 Aug 9. doi: 10.1111/j.1365-2133.2012.11213.x. [Epub ahead of print] PubMed PMID: 22880814; PubMed Central PMCID: PMC3521095. 

Euvrard S, Morelon E, Rostaing L, Goffin E, Brocard A, Tromme I, Broeders N, del Marmol V, Chatelet V, Dompmartin A, Kessler M, Serra AL, Hofbauer GF, Pouteil-Noble C, Campistol JM, Kanitakis J, Roux AS, Decullier E, Dantal J; TUMORAPA Study Group. Sirolimus and secondary skin-cancer prevention in kidney transplantation. N Engl J Med. 2012 Jul 26;367(4):329-39. doi: 10.1056/NEJMoa1204166. PubMed PMID: 22830463.

Ritchie SA, Patel MJ, Miller SJ. Therapeutic options to decrease actinic keratosis and squamous cell carcinoma incidence and progression in solid organ transplant recipients: a practical approach. Dermatol Surg. 2012 Oct;38(10):1604-21. doi: 10.1111/j.1524-4725.2012.02452.x. Epub 2012 May 30. PubMed PMID: 22646842.

Bencini PL, Galimberti MG, Pellacani G, Longo C. Application of photodynamic therapy combined with pre-illumination microneedling in the treatment of actinic keratosis in organ transplant recipients. Br J Dermatol. 2012 Nov;167(5):1193-4. doi: 10.1111/j.1365-2133.2012.11051.x. PubMed PMID: 22578273. 

Robinson JK, Turrisi R, Mallett KA, Stapleton J, Boone SL, Kim N, Riyat NV, Gordon EJ. Efficacy of an educational intervention with kidney transplant recipients to promote skin self-examination for squamous cell carcinoma detection. Arch Dermatol. 2011 Jun;147(6):689-95. doi: 10.1001/archdermatol.2011.10. Epub 2011 Feb 21. PubMed PMID: 21339418.

Jirakulaporn T, Endrizzi B, Lindgren B, Mathew J, Lee PK, Dudek AZ. Capecitabine for skin cancer prevention in solid organ transplant recipients. Clin Transplant. 2011 Jul-Aug;25(4):541-8. doi: 10.1111/j.1399-0012.2010.01348.x. Epub 2010 Nov 2. PubMed PMID: 21050273. 

Hardin J, Mydlarski PR. Systemic retinoids: chemoprevention of skin cancer in transplant recipients. Skin Therapy Lett. 2010 Jul-Aug;15(7):1-4. Review. PubMed PMID: 20700551.

Whalen FM, Jambusaria-Pahlajani A, Speck RM, Schmitz K, Schmults CD. Effect of physical activity on nonmelanoma skin cancer risk in kidney, liver, and pancreatic transplant patients. Dermatol Surg. 2010 Oct;36(10):1510-3. doi: 10.1111/j.1524-4725.2010.01674.x. PubMed PMID: 20698873. 

Marquez C, Bair SM, Smithberger E, Cherpelis BS, Glass LF. Systemic retinoids for chemoprevention of non-melanoma skin cancer in high-risk patients. J Drugs Dermatol. 2010 Jul;9(7):753-8. Review. PubMed PMID: 20677528.

Manuelli M, De Luca L, Iaria G, Tatangelo P, Sforza D, Perrone L, Bellini MI, Angelico R, Anselmo A, Tisone G. Conversion to rapamycin immunosuppression for malignancy after kidney transplantation. Transplant Proc. 2010 May;42(4):1314-6. doi: 10.1016/j.transproceed.2010.03.051. PubMed PMID: 20534289. 

Ulrich C, Johannsen A, Röwert-Huber J, Ulrich M, Sterry W, Stockfleth E. Results of a randomized, placebo-controlled safety and efficacy study of topical diclofenac 3% gel in organ transplant patients with multiple actinic keratoses. Eur J Dermatol. 2010 Jul-Aug;20(4):482-8. doi: 10.1684/ejd.2010.1010. Epub 2010 May 27. PubMed PMID: 20507841. 

Moscarelli L, Zanazzi M, Mancini G, Rossi E, Caroti L, Rosso G, Bertoni E, Salvadori M. Keratinocyte cancer prevention with ACE inhibitors, angiotensin receptor blockers or their combination in renal transplant recipients. Clin Nephrol. 2010 Jun;73(6):439-45. PubMed PMID: 20497756. 

Salgo R, Gossmann J, Schöfer H, Kachel HG, Kuck J, Geiger H, Kaufmann R, Scheuermann EH. Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. Am J Transplant. 2010 Jun;10(6):1385-93. doi: 10.1111/j.1600-6143.2009.02997.x. Epub 2010 Feb 1. PubMed PMID: 20121752.

Willey A, Mehta S, Lee PK. Reduction in the incidence of squamous cell carcinoma in solid organ transplant recipients treated with cyclic photodynamic therapy. Dermatol Surg. 2010 May;36(5):652-8. doi: 10.1111/j.1524-4725.2009.01384.x. Epub 2009 Nov 4. PubMed PMID: 19889154. 

Ulrich C, Jürgensen JS, Degen A, Hackethal M, Ulrich M, Patel MJ, Eberle J, Terhorst D, Sterry W, Stockfleth E. Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study. Br J Dermatol. 2009 Nov;161 Suppl 3:78-84. doi: 10.1111/j.1365-2133.2009.09453.x. PubMed PMID: 19775361.

Rival-Tringali AL, Euvrard S, Decullier E, Claudy A, Faure M, Kanitakis J. Conversion from calcineurin inhibitors to sirolimus reduces vascularization and thickness of post-transplant cutaneous squamous cell carcinomas. Anticancer Res. 2009 Jun;29(6):1927-32. PubMed PMID: 19528449. 

Shumack S. Systemic chemoprevention. Cancer Treat Res. 2009;146:461-6. doi: 10.1007/978-0-387-78574-5_38. Review. PubMed PMID: 19415225.

Ulrich C. Topical treatment of field cancerization. Cancer Treat Res. 2009;146:439-46. doi: 10.1007/978-0-387-78574-5_36. Review. PubMed PMID: 19415223.

Otley CC. Pretransplantation dermatologic screening and prophylaxis. Cancer Treat Res. 2009;146:391-404. doi: 10.1007/978-0-387-78574-5_31. Review. PubMed PMID: 19415218.

Kovach BT, Murphy G, Otley CC, Shumack S, Ulrich C, Stasko T. Oral retinoids for chemoprevention of skin cancers in organ transplant recipients: results of a survey. Transplant Proc. 2006 Jun;38(5):1366-8. PubMed PMID: 16797305.

Kovach BT, Sams HH, Stasko T. Systemic strategies for chemoprevention of skin cancers in transplant recipients. Clin Transplant. 2005 Dec;19(6):726-34. Review. PubMed PMID: 16313317.

Martinez JC, Otley CC, Euvrard S, Arpey CJ, Stasko T; International Transplant-Skin Cancer Collaborative. Complications of systemic retinoid therapy in organ transplant recipients with squamous cell carcinoma. Dermatol Surg. 2004 Apr;30(4 Pt 2):662-6. PubMed PMID: 15061852.


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