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Immunosuppression / Voriconazole

Knoll GA, Kokolo MB, Mallick R, Beck A, Buenaventura CD, Ducharme R, et al. Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data. BMJ. 2014;349:g6679. 

Hall EC, Engels EA, Pfeiffer RM, Segev DL. Association of Antibody Induction Immunosuppression With Cancer After Kidney Transplantation. Transplantation. 2014 Oct 21. 

He SY, Makhzoumi ZH, Singer JP, Chin-Hong PV, Arron ST. Practice variation in Aspergillus prophylaxis and treatment among lung transplant centers: a national survey. Transpl Infect Dis. 2015 Feb;17(1):14–20.

Dziunycz PJ, Lefort K, Wu X, Freiberger SN, Neu J, Djerbi N, et al. The Oncogene ATF3 is Potentiated by Cyclosporine A and Ultraviolet Light A. J Invest Dermatol. 2014 Feb 7.

Zwald FO, Spratt M, Lemos BD, Veledar E, Lawrence C, Marshall Lyon G, Chen SC. Duration of voriconazole exposure: an independent risk factor for skin cancer after lung transplantation. Dermatol Surg. 2012 Aug;38(8):1369-74. doi: 10.1111/j.1524-4725.2012.02418.x. Epub 2012 May 2. PubMed PMID: 22551390. 

Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF, Byrne C. The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. Oncogene. 2012 Aug 13. doi: 10.1038/onc.2012.338. [Epub ahead of print] PubMed PMID: 22890326. 

Han W, Soltani K, Ming M, He YY. Deregulation of XPC and CypA by cyclosporin A: an immunosuppression-independent mechanism of skin carcinogenesis. Cancer Prev Res (Phila). 2012 Sep;5(9):1155-62. doi: 10.1158/1940-6207.CAPR-12-0185-T. Epub 2012 Jul 30. PubMed PMID: 22846842; PubMed Central PMCID: PMC3435459.

Arumugam A, Walsh SB, Xu J, Afaq F, Elmets CA, Athar M. Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs. Biochem Biophys Res Commun. 2012 Aug 24;425(2):177-81. doi: 10.1016/j.bbrc.2012.07.062. Epub 2012 Jul 20. PubMed PMID: 22820192; PubMed  Central PMCID: PMC3476731.

Stucker F, Marti HP, Hunger RE. Immunosuppressive drugs in organ transplant recipients--rationale for critical selection. Curr Probl Dermatol. 2012;43:36-48. doi: 10.1159/000335148. Epub 2012 Feb 17. Review. PubMed PMID: 22377918.

Kuschal C, Thoms KM, Schubert S, Schäfer A, Boeckmann L, Schön MP, Emmert S. Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair. Exp Dermatol. 2012 Jan;21(1):2-6. doi: 10.1111/j.1600-0625.2011.01413.x. Review. PubMed PMID: 22151386. 

Braconnier P, Del Marmol V, Broeders N, Kianda M, Massart A, Lemy A, Ghisdal L, Le Moine A, Madhoun P, Racapé J, Abramowicz D, Wissing KM. Combined introduction of anti-IL2 receptor antibodies, mycophenolic acid and tacrolimus: effect on malignancies after renal transplantation in a single-centre retrospective cohort study. Nephrol Dial Transplant. 2012 Jun;27(6):2547-53. doi: 10.1093/ndt/gfr627. Epub 2011 Nov 28. PubMed PMID: 22123748.

Singer JP, Boker A, Metchnikoff C, Binstock M, Boettger R, Golden JA, Glidden DV, Arron ST. High cumulative dose exposure to voriconazole is associated with cutaneous squamous cell carcinoma in lung transplant recipients. J Heart Lung Transplant. 2012 Jul;31(7):694-9. doi: 10.1016/j.healun.2012.02.033. Epub 2012 Apr 6. PubMed PMID: 22484291; PubMed Central PMCID: PMC3371090.

Brem R, Karran P. Multiple forms of DNA damage caused by UVA photoactivation of DNA 6-thioguanine. Photochem Photobiol. 2012 Jan-Feb;88(1):5-13. doi: 10.1111/j.1751-1097.2011.01043.x. Epub 2011 Dec 16. Review. PubMed PMID: 22077233.

Muellenhoff MW, Koo JY. Cyclosporine and skin cancer: an international dermatologic perspective over 25 years of experience. A comprehensive review and pursuit to define safe use of cyclosporine in dermatology. J Dermatolog Treat. 2012 Aug;23(4):290-304. doi: 10.3109/09546634.2011.590792. Epub 2011 Sep 21. Review. PubMed PMID: 21936704. 

Feldmeyer L, Hofbauer GF, Böni T, French LE, Hafner J. Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing. Br J Dermatol. 2012 Feb;166(2):422-4. doi: 10.1111/j.1365-2133.2011.10591.x. Epub 2011 Dec 5. PubMed PMID: 21895616. 

Attard NR, Karran P. UVA photosensitization of thiopurines and skin cancer in organ transplant recipients. Photochem Photobiol Sci. 2012 Jan;11(1):62-8. doi: 10.1039/c1pp05194f. Epub 2011 Aug 23. Review. PubMed PMID: 21860872.

Parada MT, Alba A, Sepúlveda C, Melo J. Long-term use of everolimus in lung transplant patients. Transplant Proc. 2011 Jul-Aug;43(6):2313-5. doi: 10.1016/j.transproceed.2011.06.010. PubMed PMID: 21839261. 

Kuschal C, Thoms KM, Boeckmann L, Laspe P, Apel A, Schön MP, Emmert S. Cyclosporin A inhibits nucleotide excision repair via downregulation of the xeroderma pigmentosum group A and G proteins, which is mediated by calcineurin inhibition. Exp Dermatol. 2011 Oct;20(10):795-9. doi: 10.1111/j.1600-0625.2011.01320.x. Epub 2011 Jun 24. PubMed PMID: 21707758.

Leblanc KG Jr, Hughes MP, Sheehan DJ. The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients. Dermatol Surg. 2011 Jun;37(6):744-9. doi: 10.1111/j.1524-4725.2011.01973..x. Review. PubMed PMID: 21605234. 

Leblanc Jr KG, Hughes MP, Sheehan DJ. The Role of Sirolimus in the Prevention of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients. Dermatol Surg. 2011 Apr 14. doi: 10.1111/j.1524-4725.2011.01973.x. [Epub ahead of print] PubMed PMID: 21492310. 

Xu J, Walsh SB, Verney ZM, Kopelovich L, Elmets CA, Athar M. Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway. Biochem Biophys Res Commun. 2011 May 13;408(3):363-8. doi: 10.1016/j.bbrc.2011.02.039. Epub 2011 Feb 17. PubMed PMID: 21333626; PubMed Central PMCID: PMC3095674.

Walsh SB, Xu J, Xu H, Kurundkar AR, Maheshwari A, Grizzle WE, Timares L, Huang CC, Kopelovich L, Elmets CA, Athar M. Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway. Mol Carcinog. 2011 Jul;50(7):516-27. doi: 10.1002/mc.20744. Epub 2011 Feb 9. PubMed PMID:21308804; PubMed Central PMCID: PMC3110643.

Wang Y, Wang XY, Subjeck JR, Shrikant PA, Kim HL. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br J Cancer. 2011 Feb 15;104(4):643-52. doi: 10.1038/bjc.2011.15. Epub 2011 Feb 1. PubMed PMID: 21285988; PubMed Central PMCID: PMC3049595.

Ibrahim SF, Singer JP, Arron ST. Catastrophic squamous cell carcinoma in lung transplant patients treated with voriconazole. Dermatol Surg. 2010 Nov;36(11):1752-5. doi: 10.1111/j.1524-4725.2010.01596.x. PubMed PMID: 20533939; PubMed Central PMCID: PMC3046628.

C, Kwak EJ, Silveira FP, Clancy CJ. Voriconazole exposure and geographic location are independent risk factors for squamous cell carcinoma of the skin among lung transplant recipients. J Heart Lung Transplant. 2010 Nov;29(11):1240-4. doi: 10.1016/j.healun.2010.05.022. Epub 2010 Jun 29. PubMed PMID: 20591690.

Han W, Ming M, He TC, He YY. Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis. J Biol Chem. 2010 Apr 9;285(15):11369-77. doi: 10.1074/jbc.M109.028142. Epub 2010 Feb 12. PubMed PMID: 20154081; PubMed Central PMCID: PMC2857015.

van Leeuwen MT, Webster AC, McCredie MR, Stewart JH, McDonald SP, Amin J, Kaldor JM, Chapman JR, Vajdic CM, Grulich AE. Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: population based retrospective cohort study. BMJ. 2010 Feb 11;340:c570. doi: 10.1136/bmj.c570. PubMed PMID: 20150194; PubMed Central PMCID: PMC2820609.

de Gruijl FR, Koehl GE, Voskamp P, Strik A, Rebel HG, Gaumann A, de Fijter JW, Tensen CP, Bavinck JN, Geissler EK. Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis. Int J Cancer. 2010 Aug 15;127(4):796-804. doi: 10.1002/ijc.25097. PubMed PMID: 19998342.

Norman KG, Canter JA, Shi M, Milne GL, Morrow JD, Sligh JE. Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients. Mitochondrion. 2010 Mar;10(2):94-101. doi: 10.1016/j.mito.2009.10.001. Epub 2009 Oct 31. PubMed PMID: 19836469.

 Wisgerhof HC, Hameetman L, Tensen CP, Morreau H, de Fijter JW, Bouwes Bavinck JN, Willemze R, de Gruijl FR. Azathioprine-induced microsatellite instability is not observed in skin carcinomas of organ transplant recipients. J Invest Dermatol. 2009 May;129(5):1307-9. doi: 10.1038/jid.2008.397. Epub 2009 Jan 1. PubMed PMID: 19122648.

Duncan FJ, Wulff BC, Tober KL, Ferketich AK, Martin J, Thomas-Ahner JM, Allen SD, Kusewitt DF, Oberyszyn TM, Vanbuskirk AM. Clinically relevant immunosuppressants influence UVB-induced tumor size through effects on inflammation and angiogenesis. Am J Transplant. 2007 Dec;7(12):2693-703. Epub 2007 Oct 17. PubMed PMID: 17941958.

Brewer JD, Otley CC, Christenson LJ, Phillips PK, Roenigk RK, Weaver AL. The effects of sirolimus on wound healing in dermatologic surgery. Dermatol Surg. 2008 Feb;34(2):216-23. Epub 2007 Dec 17. PubMed PMID: 18093198.

Otley CC, Griffin MD, Charlton MR, Edwards BS, Neuburg M, Stasko T; Reduction of Immunosuppression Task Force of the International Transplant Skin Cancer Collaborative. Reduction of immunosuppression for transplant-associated skin cancer: thresholds and risks. Br J Dermatol. 2007 Dec;157(6):1183-8. Epub 2007 Oct 4. PubMed PMID: 17916206.

Herman S, Rogers HD, Ratner D. Immunosuppression and squamous cell carcinoma: a focus on solid organ transplant recipients. Skinmed. 2007 Sep-Oct;6(5):234-8. Review. PubMed PMID: 17786101.

Neuburg M. Transplant-associated skin cancer: role of reducing immunosuppression. J Natl Compr Canc Netw. 2007 May;5(5):541-9. Review. PubMed PMID: 17509256.

Otley CC, Maragh SL. Reduction of immunosuppression for transplant-associated skin cancer: rationale and evidence of efficacy. Dermatol Surg. 2005 Feb;31(2):163-8. Review. PubMed PMID: 15762208.

Otley CC, Coldiron BM, Stasko T, Goldman GD. Decreased skin cancer after cessation of therapy with transplant-associated immunosuppressants. Arch Dermatol. 2001 Apr;137(4):459-63. PubMed PMID: 11295926.

Gupta AK, Rocher LL, Schmaltz SP, Goldfarb MT, Brown MD, Ellis CN, Voorhees JJ. Short-term changes in renal function, blood pressure, and electrolyte levels in patients receiving cyclosporine for dermatologic disorders. Arch Intern Med. 1991 Feb;151(2):356-62. PubMed PMID: 1992963.

Brown MD, Gupta AK, Ellis CN, Rocher LL, Voorhees JJ. Therapy of dermatologic disease with cyclosporin A. Adv Dermatol. 1989;4:3-27; discussion 28. Review. PubMed PMID: 2701795.


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