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Basic Science / Translational

Li YY, Hanna GJ, Laga AC, Haddad RI, Lorch JH, Hammerman PS. Genomic analysis of metastatic cutaneous squamous cell carcinoma. Clin Cancer Res. 2015 Jan 14. 

South AP, Purdie KJ, Watt SA, Haldenby S, Breems den NY, Dimon M, et al. NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol. 2014 Oct;134(10):2630–8. 

Fusi C, Materazzi S, Minocci D, Maio V, Oranges T, Massi D, et al. Transient receptor potential vanilloid 4 (TRPV4) is downregulated in keratinocytes in human non-melanoma skin cancer. J Invest Dermatol. 2014 Sep;134(9):2408–17. 

Lee CS, Bhaduri A, Mah A, Johnson WL, Ungewickell A, Aros CJ, et al. Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma. Nat Genet. 2014 Oct;46(10):1060–2. 

Zhang L, Ge Y, Fuchs E. miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival. Genes Dev. 2014 Nov 15;28(22):2532–46. 

Anand S, Ebner J, Warren CB, Raam MS, Piliang M, Billings SD, et al. C/EBP Transcription Factors in Human Squamous Cell Carcinoma: Selective Changes in Expression of Isoforms Correlate with the Neoplastic State. PLoS ONE. 2014;9(11):e112073. 

Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, et al. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014 Oct 10. 

Sherston SN, Vogt K, Schlickeiser S, Sawitzki B, Harden PN, Wood KJ. Demethylation of the TSDR Is a Marker of Squamous Cell Carcinoma in Transplant Recipients. Am J Transplant. 2014 Sep 23. 

Riihilä P, Nissinen L, Farshchian M, Kivisaari A, Ala-Aho R, Kallajoki M, et al. Complement Factor I Promotes Progression of Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2014 Sep 3. 

Zou X-Y, Ding D, Zhan N, Liu X-M, Pan C, Xia Y-M. Glyoxalase I is Differentially Expressed in Cutaneous Neoplasms and Contributes to the Progression of Squamous Cell Carcinoma. J Invest Dermatol. 2014 Sep 3.

Hanlon A, O'Neill M, Fang F, Chen H, Lott J, Wigger M, et al. Gene Expression Profiling for Cardiac Rejection Surveillance is not Predictive of Post-Transplantation Skin Cancer. Dermatol Surg. 2013 Oct;39(10):1507–13.

Belkin DA, Mitsui H, Wang CQF, Gonzalez J, Zhang S, Shah KR, et al. CD200 Upregulation in Vascular Endothelium Surrounding Cutaneous Squamous Cell Carcinoma. Arch Dermatol. 2012 Dec 17;:1–9.

Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C. Defining the mode of tumour growth by clonal analysis. Nature. 2012 Aug 23;488(7412):527-30. doi: 10.1038/nature11344. PubMed PMID: 22854777.

Verneuil L, Varna M, Leboeuf C, Plassa LF, Elbouchtaoui M, Loisel-Ferreira I, Bouhidel F, Peraldi MN, Lebbé C, Ratajczak P, Janin A. Donor-Derived Keratinocytes in Actinic Keratosis and Squamous Cell Carcinoma in Patients with Kidney Transplant. J Invest Dermatol. 2012 Nov 29. doi: 10.1038/jid.2012.422. [Epub ahead of print] PubMed PMID: 23190878.

Mühleisen B, Petrov I, Frigerio S, Dziunycz P, French LE, Hofbauer GF. Pronounced allelic imbalance at D9S162 in skin squamous cell carcinoma of organ transplant recipients. Arch Dermatol. 2012 Jun;148(6):697-703. doi: 10.1001/archdermatol.2012.107. PubMed PMID: 22508773.

Gomez-Lira M, Tessari G, Mazzola S, Malerba G, Rugiu C, Naldi L, Nacchia F, Valerio F, Anna B, Forni A, Boschiero L, Sandrini S, Faggian G, Girolomoni G, Turco A. Analysis of the 3'UTR of the prostaglandin synthetase-2 (PTGS-2/COX-2) gene in non-melanoma skin cancer after organ transplantation. Exp Dermatol. 2011  Dec;20(12):1025-7. doi: 10.1111/j.1600-0625.2011.01381.x. Epub 2011 Oct 13. PubMed PMID: 21995456.

Athar M, Kopelovich L. Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention. Cancer Prev Res (Phila). 2011 Jul;4(7):957-61. doi: 10.1158/1940-6207.CAPR-11-0266. PubMed PMID: 21733819; PubMed Central PMCID: PMC3136877.

Rangwala S, Tsai KY. Roles of the immune system in skin cancer. Br J Dermatol. 2011  ov;165(5):953-65. doi: 10.1111/j.1365-2133.2011.10507.x. Review.  PubMed PMID: 21729024; PubMed Central PMCID: PMC3197980.

Dotto GP. Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis. Cancer Res. 2011 Mar 15;71(6):2029-33. doi: 10.1158/0008-5472.CAN-10-3750. Review. PubMed PMID: 21406393.

Athar M, Walsh SB, Kopelovich L, Elmets CA. Pathogenesis of nonmelanoma skin cancers in organ transplant recipients. Arch Biochem Biophys. 2011 Apr 15;508(2):159-63. doi: 10.1016/j.abb.2011.01.004. Epub 2011 Jan 11. Review. PubMed PMID: 21232524; PubMed Central PMCID: PMC3063391.

Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature. 2010 May 20;465(7296):368-72. doi: 10.1038/nature08996. PubMed PMID: 20485437; PubMed Central PMCID: PMC3050632.

Kosmidis M, Dziunycz P, Suárez-Fariñas M, Mühleisen B, Schärer L, Läuchli S, Hafner J, French LE, Schmidt-Weber C, Carucci JA, Hofbauer GF. Immunosuppression affects CD4+ mRNA expression and induces Th2 dominance in the microenvironment of cutaneous squamous cell carcinoma in organ transplant recipients. J Immunother. 2010 Jun;33(5):538-46. doi: 10.1097/CJI.0b013e3181cc2615. PubMed PMID: 20463594.

Aubin F, Courivaud C, Bamoulid J, Loupy A, Deschamps M, Ferrand C, Le Corre D, Tiberghien P, Chalopin JM, Legendre C, Thervet E, Humbert P, Saas P, Ducloux D. Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism at position-765 on skin cancer after renal transplantation. J Invest Dermatol. 2010 Aug;130(8):2134-6. doi: 10.1038/jid.2010.116. Epub 2010 May 6. PubMed PMID: 20445548.

Dziunycz P, Hofbauer GF. Immune phenotype of peripheral blood cells and skin squamous cell carcinoma in organ transplant recipients. Expert Rev Clin Immunol. 2010 May;6(3):359-62. doi: 10.1586/eci.10.21. PubMed PMID: 20441422.

Malek A, Catapano CV, Czubayko F, Aigner A. A sensitive polymerase chain reaction-based method for detection and quantification of metastasis in human xenograft mouse models. Clin Exp Metastasis. 2010 Apr;27(4):261-71. doi: 10.1007/s10585-010-9324-1. Epub 2010 Apr 4. PubMed PMID: 20364399.

Laing ME, Cummins R, O'Grady A, O'Kelly P, Kay EW, Murphy GM. Aberrant DNA methylation associated with MTHFR C677T genetic polymorphism in cutaneous squamous cell carcinoma in renal transplant patients. Br J Dermatol. 2010 Aug;163(2):345-52. doi: 10.1111/j.1365-2133.2010.09774.x. Epub 2010 Mar 19. PubMed PMID: 20346029.

Begnini A, Tessari G, Turco A, Malerba G, Naldi L, Gotti E, Boschiero L, Forni A, Rugiu C, Piaserico S, Fortina AB, Brunello A, Cascone C, Girolomoni G, Gomez Lira M. PTCH1 gene haplotype association with basal cell carcinoma after transplantation. Br J Dermatol. 2010 Aug;163(2):364-70. doi: 10.1111/j.1365-2133.2010.09776.x. Epub 2010 Mar 23. PubMed PMID: 20346027.

Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E, Hata R. Chemokine CXCL14/BRAK transgenic mice suppress growth of carcinoma cell transplants. [corrected]. Transgenic Res. 2010 Dec;19(6):1109-17. doi: 10.1007/s11248-010-9384-7. Epub 2010 Mar 24. Erratum in: Transgenic Res. 2010 Dec;19(6):1119. PubMed PMID: 20333465.

Borie C, Euvrard S, Vérola O, Buhard O, Barete S, Molina JM, Kanitakis J, Kérob D, Lebbé C, Duval A. No evidence for microsatellite instability in immunodeficiency-related skin cancers. Am J Transplant. 2010 Jan;10(1):192-3. doi: 10.1111/j.1600-6143.2009.02862.x. Epub 2009 Nov 4. PubMed PMID: 19889122.

Ku TK, Crowe DL. Impaired T lymphocyte function increases tumorigenicity and decreases tumor latency in a mouse model of head and neck cancer. Int J Oncol. 2009 Nov;35(5):1211-21. PubMed PMID: 19787277.

Kuivanen T, Jeskanen L, Kyllönen L, Isaka K, Saarialho-Kere U. Matrix metalloproteinase-26 is present more frequently in squamous cell carcinomas of immunosuppressed compared with immunocompetent patients. J Cutan Pathol. 2009 Sep;36(9):929-36. doi: 10.1111/j.1600-0560.2009.01188.x. PubMed PMID: 19674198.

Harradine KA, Ridd K, Saunier EF, Clermont FF, Perez-Losada J, Moore DH, Epstein EH Jr, Bastian BC, Akhurst RJ. Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients. Clin Cancer Res. 2009 Aug 15;15(16):5101-7. doi: 10.1158/1078-0432.CCR-08-3286. Epub 2009 Aug 11. PubMed PMID: 19671862; PubMed Central PMCID: PMC2812428.

Kepron C, Reis P, Bharadwaj R, Shaw J, Kamel-Reid S, Ghazarian D. Identification of genomic predictors of non-melanoma skin cancer in solid organ transplant recipients. Eur J Dermatol. 2009 May-Jun;19(3):278-80. doi: 10.1684/ejd.2009.0649. Epub 2009 Mar 24. PubMed PMID: 19307168.

Dworkin AM, Tober KL, Duncan FJ, Yu L, VanBuskirk AM, Oberyszyn TM, Toland AE. Chromosomal aberrations in UVB-induced tumors of immunosuppressed mice. Genes Chromosomes Cancer. 2009 Jun;48(6):490-501. doi: 10.1002/gcc.20657. PubMed PMID: 19296524; PubMed Central PMCID: PMC2739622.

Wulff BC, Kusewitt DF, VanBuskirk AM, Thomas-Ahner JM, Duncan FJ, Oberyszyn TM. Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A. J Invest Dermatol. 2008 Oct;128(10):2467-73. Epub 2008 May 8. PubMed PMID: 18463679; PubMed Central PMCID: PMC2606089.

Hatton JL, Parent A, Tober KL, Hoppes T, Wulff BC, Duncan FJ, Kusewitt DF, VanBuskirk AM, Oberyszyn TM. Depletion of CD4+ cells exacerbates the cutaneous response to acute and chronic UVB exposure. J Invest Dermatol. 2007 Jun;127(6):1507-15. Epub 2007 Mar 15. PubMed PMID: 17363918.

Xu Q, Lee J, Jankowska-Gan E, Schultz J, Roenneburg DA, Haynes LD, Kusaka S, Sollinger HW, Knechtle SJ, VanBuskirk AM, Torrealba JR, Burlingham WJ. Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol. 2007 Mar 15;178(6):3983-95. Erratum in: J Immunol. 2007 Jun 1;178(11):7488. Roennburg, Drew A [corrected to Roenneburg, Drew A]. PubMed PMID: 17339499.

Arbiser JL, Mann KP, Losken EM, Cohen C, Reddy K, Kokko K, Pollack B, Fan CY, O'Reilly F. Presence of p16 hypermethylation and Epstein-Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin. J Am Acad Dermatol. 2006 Nov;55(5):794-8. Epub 2006 Sep 1. PubMed PMID: 17052484.

VanBuskirk AM, Lesinski GB, Nye KJ, Carson WE, Yee LD. TGF-beta inhibition of CTL re-stimulation requires accessory cells and induces peroxisome-proliferator-activated receptor-gamma (PPAR-gamma). Am J Transplant. 2006 Aug;6(8):1809-19. PubMed PMID: 16889541.

Dierksheide JE, Baiocchi RA, Ferketich AK, Roychowdhury S, Pelletier RP, Eisenbeis CF, Caligiuri MA, VanBuskirk AM. IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice. Blood. 2005 Feb 15;105(4):1558-65. Epub 2004 Oct 21. PubMed PMID: 15498860.

Valujskikh A, VanBuskirk AM, Orosz CG, Heeger PS. A role for TGFbeta and B cells in immunologic tolerance after intravenous injection of soluble antigen. Transplantation. 2001 Aug 27;72(4):685-93. PubMed PMID: 11544432.

VanBuskirk AM, Malik V, Xia D, Pelletier RP. A gene polymorphism associated with posttransplant lymphoproliferative disorder. Transplant Proc. 2001 Feb-Mar;33(1-2):1834. PubMed PMID: 11267533.

Bickerstaff AA, VanBuskirk AM, Wakely E, Orosz CG. Transforming growth factor-beta and interleukin-10 subvert alloreactive delayed type hypersensitivity in cardiac allograft acceptor mice. Transplantation. 2000 Apr 15;69(7):1517-20. PubMed PMID: 10798784.

Carrodeguas L, Orosz CG, Waldman WJ, Sedmak DD, Adams PW, VanBuskirk AM. Trans vivo analysis of human delayed-type hypersensitivity reactivity. Hum Immunol. 1999 Aug;60(8):640-51. PubMed PMID: 10439310.

Sirak JH, Orosz CG, Roopenian DC, Wakely E, VanBuskirk AM. Cardiac allograft tolerance: failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns. Transplantation. 1998 May 27;65(10):1352-6. PubMed PMID: 9625018.

Orosz CG, Huang EH, Bergese SD, Sedmak DD, Birmingham DJ, Ohye RG, VanBuskirk AM. Prevention of acute murine cardiac allograft rejection: anti-CD4 or anti-vascular cell adhesion molecule one monoclonal antibodies block acute rejection but permit persistent graft-reactive alloimmunity and chronic tissue remodelling. J Heart Lung Transplant. 1997 Sep;16(9):889-904. PubMed PMID: 9322138.

Fairchild RL, VanBuskirk AM, Kondo T, Wakely ME, Orosz CG. Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. Transplantation. 1997 Jun 27;63(12):1807-12. PubMed PMID: 9210509.

Orosz CG, Wakely E, Sedmak DD, Bergese SD, VanBuskirk AM. Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody. Transplantation. 1997 Apr 27;63(8):1109-17. PubMed PMID: 9133472.

Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK. Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation. 1997 Mar 15;63(5):619-24. Review. PubMed PMID: 9075827.

VanBuskirk AM, Wakely ME, Orosz CG. Acute rejection of cardiac allografts by noncytolytic CD4(+) T cell populations. Transplantation. 1996 Jul 27;62(2):300-2. PubMed PMID: 8755833.

VanBuskirk AM, Wakely ME, Orosz CG. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation. 1996 Jul 27;62(2):229-38. PubMed PMID: 8755821.

Orosz CG, Wakely E, Bergese SD, VanBuskirk AM, Ferguson RM, Mullet D, Apseloff G, Gerber N. Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anti-CD4 monoclonal antibody. Transplantation. 1996 Mar 15;61(5):783-91. PubMed PMID: 8607184.

Orosz CG, Bergese SD, Huang EH, Vanbuskirk AM. Immunologic characterizationof murine cardiac allograft recipients with long-term graft survival due to anti-VCAM-1 or anti-CD4 monoclonal antibody therapy. Transplant Proc. 1995 Feb;27(1):387-8. PubMed PMID: 7533414.

Pelletier RP, Hennessy PK, Adams PW, VanBuskirk AM, Ferguson RM, Orosz CG. Clinical significance of MHC-reactive alloantibodies that develop after kidney or kidney-pancreas transplantation. Am J Transplant. 2002 Feb;2(2):134-41. PubMed PMID: 12099515.

Geissler F, Jankowska-Gan E, Sollinger H, Kalayoglu M, VanBuskirk AM, Orosz CG, Burlingham W. Immunoregulation in liver transplant recipients: possible evidence of tolerance by DTH assay. Transplant Proc. 2001 Feb-Mar;33(1-2):1377. PubMed PMID: 11267335.

VanBuskirk AM, Burlingham WJ, Jankowska-Gan E, Chin T, Kusaka S, Geissler F, Pelletier RP, Orosz CG. Human allograft acceptance is associated with immune regulation. J Clin Invest. 2000 Jul;106(1):145-55. PubMed PMID: 10880058; PubMed Central PMCID: PMC314359.

Orosz CG, VanBuskirk AM. Immune mechanisms of acute rejection. Transplant Proc. 1998 May;30(3):859-61. Review. PubMed PMID: 9595126.

Zhang S, Fujita H, Mitsui H, Yanofsky VR, Fuentes-Duculan J, Pettersen JS, et al. Increased Tc22 and Treg/CD8 Ratio Contribute to Aggressive Growth of Transplant Associated Squamous Cell Carcinoma. PLoS ONE. 2013;8(5):e62154.

VanBuskirk AM, Wakely ME, Sirak JH, Orosz CG. Patterns of allosensitization in allograft recipients: long-term cardiac allograft acceptance is associated with active alloantibody production in conjunction with active inhibition of alloreactive delayed-type hypersensitivity. Transplantation. 1998 Apr 27;65(8):1115-23. PubMed PMID: 9583874.

Sirak J, Orosz CG, Wakely E, VanBuskirk AM. Alloreactive delayed-type hypersensitivity in graft recipients: complexity of responses and divergence from acute rejection. Transplantation. 1997 May 15;63(9):1300-7. PubMed PMID: 9158025.



Updated on Friday, January 11th, 2013

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